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Conception and pregnancy – McMaster Pathophysiology Review
Interconnecting channels ( When the decidual capillaries are invaded, the lacunae fill with blood The lacunae become larger and merge as the syncytiotrophoblast thins, until the syncytiotrophoblast is...
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Instructions – McMaster Pathophysiology Review
McMaster Pathophysiology Review Instructions Welcome to the McMaster Pathophysiology Review! This is a place where you can find explanations of the mechanisms of various diseases. Through our preclerk...
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Introduction to immunology – McMaster Pathophysiology Review
Trends Immunol. 2001 May;22(5):235-6. Nat Immunol. 2012 Feb 16;13(3):214-22. Medicine. 2009 Oct 37(10): 510-517 Jpn J. Infec Dis. 2004 57: 236-247. Microorganisms that cause disease in humans and anim...
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Introduction to neoplasia – McMaster Pathophysiology Review
Most carcinomas are initiated by loss of a tumour suppressor gene Subsequent progression to malignancy involves both additional gain of oncogenes and loss of tumour suppressors in all types of cancer...
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Ischemic heart disease – McMaster Pathophysiology Review
N Engl J Med. 2005 Jun 16;352(24):2524-33. Lilly, Pathophysiology of Heart Disease, 2007. Ischemic heart disease: a condition in which imbalance between myocardial oxygen supply and demand, most ofte...
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Chronic obstructive pulmonary disease (COPD) – McMaster Pathophysiology Review
Cigarette smoke Presence of smoke particles in the lungs leads to an inflammatory response with increased macrophage and neutrophil infiltration into the lungs. These immune cells release cytokines, c...